PDE5 inhibitors are drugs that enhance the relaxing effect of NO (nitric oxide), by inhibiting (suppressing) the phosphodiesterase of the fifth type (PDE5), as well as increasing the concentration of cyclic guanosine monophosphate (cGMP) in the cavernous bodies of the penis. PDE5 inhibitors are used in the treatment of ED in men.
The group of PDE5 inhibitors includes:
1. Tadalafil (the commercial name of the drug is Cialis);
2. Sildenafil (commercial name of the drug is Viagra);
3. Avanafil (commercial name of the drug is Stendra);
4. Vardenafil (commercial name of the drug is Levitra), and some other less-known drugs.
In this article, we will look at the common signs and the difference between Cialis and Viagra, since these medications are the most popular among men suffering from erectile dysfunction (according to statistics). You can get Cialis online (as well as generic Viagra) in most of the online pharmacies.
The Main Features of Cialis and Viagra
These products are perfectly combined with phytopreparations (plant-based meds). According to clinical studies, the use of PDE5 inhibitors, together with phytopreparations, is not dangerous and ineffective. These drugs have found wide application in the therapy of patients with moderate as well as with serious erectile dysfunctions of organic, psychogenic, or mixed etiology associated with a wide range of concomitant phenomena, including cardiovascular diseases (which are not associated with the use of nitrate drugs), diabetes, pelvic surgery, Parkinson’s disease, and spinal cord injuries. The advantages of these drugs include: reversibility, painlessness, convenience, and relatively “natural” erection and sexual intercourse.
Cialis and Viagra – Myths and Truths
Before conducting a comparison of the drugs, it is worth noting that they should never be taken if you are using medicines containing special, active substances called nitrates. If you ignore this, it is quite possible that during sexual intercourse your arterial pressure may reach a point that is life threatening.
Taking the medications, you should not expect that the sexual organ itself will come to the right state after ingestion of Cialis or Viagra. It’s a delusion. The drugs help to improve blood circulation. That is, they allow a man to reach the desired level of erection, which cannot occur without sexual stimulation. After sex, the sexual organ returns to its normal state (except for the occurrence of side effects, such as priapism).
In any case, before choosing Viagra vs Cialis and taking the drugs, you should consult a doctor. Perhaps he/she will advise you to take another drug, referring to the characteristics of your body. In addition, if you once had a hypersensitivity to any medication, then you cannot take any drug without consulting a specialist.
The drugs have been on the market for a long time, and there are many myths about them. The most common one is that the medications cure ED. This is a myth because Viagra and Cialis don’t fully heal ED.
The use of these drugs can be called symptomatic therapy.
Some believe that if you take these pills, then in this way you can prevent the transmission of sexual diseases. Alas, but this is a deep delusion. Therefore, methods of contraception should be used during the course of anti-ED treatment. And the last thing, the drugs are neither hormones nor aphrodisiacs.
Viagra vs. Cialis – The Main Difference Between the Drugs
There are three criteria by which the main differences between the drugs can be determined:
1. The onset of effect. Viagra begins to act approximately 30-40 minutes after ingestion. Cialis is faster, in about 20-30 minutes.
2. Duration of action. The positive effect of the blue pill (Viagra) persists for 4-6 hours and disappears completely 12 hours after ingestion. Cialis is stable for 1.5 days. This is one of the key advantages of Cialis, since this medication provides a man with the possibility of spontaneous, sexual intercourse for a long time (for example, between Friday night and Sunday morning). Therefore, men who use Cialis do not suffer from psychological dependence, which is associated with the need to use pills before sexual penetration.
3. Compatibility with high-fat foods & alcohol. Very fatty foods affect the absorption rate of Viagra. If you eat such food, the desired effect can occur not in half an hour, but in two hours. The onset of the effect of taking Cialis does not depend on the intake of food, which is an undoubted advantage of this drug. As for alcohol, Cialis is more compatible with alcoholic beverages than Viagra.
Cialis vs. Viagra – Comparison of Effectiveness
According to clinical studies, Viagra is effective for 82 percent of men. The same indicator of Cialis is about 81%. This minimal difference can be a common statistical error, so the effectiveness of both drugs is approximately the same.
Viagra vs. Cialis – Cost Difference Between the Drugs
The cost difference between the drugs isn’t large. According to the information placed on the Costco Wholesale website (where you have a possibility to buy Cialis/Viagra online), one 10mg or 20mg pill of Cialis costs around $63 (10-pill pack costs $635.34). A pill containing a 2.5 and 5mg dosage are cheaper: around $12 per tablet (10-pill pack costs $122.35). As for Viagra, one 100mg pill costs $64. The price of one 25 or 50mg pill is $69. If you find good discounts or an online coupon, you can buy the drugs cheaper.
Cialis vs. Viagra – Can the Drugs be Used Together?
Simultaneous use of the drugs hasn’t been tested in clinical studies. Their compatibility is unknown. Therefore, it is not safe to take Viagra and Cialis together. It is better to do it separately. These are almost similar drugs. So you can try both, but on different days, and evaluate which one suits you better.
Some Users’ Reviews
According to users’ reviews, both remedies are effective. Of course, there are some negative reviews as the drugs aren’t suitable for all patients. Some men complain of side effects, such as headaches and vision problems. It should be noted that many reviews of Cialis are associated with the treatment of prostate enlargement while Viagra is not used for this purpose.
Conclusion: Which is Better?
Cialis vs. Viagra: Which is better? Some pharmacokinetic properties of Viagra (short, half-life, worsening of effect after eating and alcohol consumption) lead to the necessity of a planned, sexual intercourse encounter, a decrease in romanticism, a loss of spontaneity of sexual activity, a restriction in time and frequency of sexual attempts.
From the standpoint of these facts, Cialis is preferable for a certain group of patients. Its action does not depend on ingesting various kinds of food and alcohol. These two things are often desirable as components of sexual relationships. Moreover, the duration of the action of Cialis (36 hours) allows a man to take a safer attitude to the so-called planning of sexual intercourse and to maintain the spontaneity and romanticism of sexual relations.
However, many patients choose Viagra. This drug has been on the market for a longer time, so many men trust it more.
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